Error: ORA-32102: invalid OCI handle connecting Oracle via node.js

Just had this same issue. Move the connection.close into your execute function. Because this is Node and things are running non blocking, it is closing your connection before the results are sent back.

var oracle = require('oracle');

oracle.connect({ "hostname": "hostname", "user": "user", "password": "password" },
  function(err, connection) {

    if(err){ console.log("Connect err:" + err); }
    if(connection){ console.log("Connection:" + connection); }

    console.log(connection);
    console.log("........");

    // selecting rows
    connection.execute("SELECT * FROM AUTOLOAN_MASTER WHERE RELIGION = :1", ['R'], 
      function(err, results) {
        if (err) {
          console.log('Failed to query table in Oracle: '+ err);
          req.results = null;
        }
        console.log(req);
        console.log(req.results);
        connection.close(); // Moved inside execute callback
   });
});