As you can see here: https://github.com/visionmedia/express/blob/master/examples/multipart/index.js Express support file uploads by default and store each uploaded file on the temp folder for later use.
My question is: Is it safe?
As I see it, an attacker can fill up all the temp folder with garbage files without any control on it. Should i check each POST request and delete any unused file?
Let me suggest two solutions to your problem.
Make sure that you only accept a maximum number of x uploads from the same ip address during during a 24 hour period. Combine this solution with solution 1 for maximum effect. One way of implementing this, is to have a global object with upload counts for each ip address, and then clear it out every 24 hours.
var uploads = {}
setInterval(function(){
uploads = {}
}, 24*60*60*1000); //Run every 24 hours
var onUpload = function(request, file){
if(uploads[req.ip] > maxUploadsAllowedPrUser)
fs.unlink(file) //Delete the file
else
uploads[req.ip]++ //Keep the file, and increase count
}