I've been working on a module for sending mouse and keyboard events, RobotJS.

Example code:

var robot = require("robotjs");

//Get the mouse position, retuns an object with x and y. 
var mouse=robot.getMousePos();
console.log("Mouse is at x:" + mouse.x + " y:" + mouse.y);

//Move the mouse down by 100 pixels.
robot.moveMouse(mouse.x,mouse.y+100);

//Left click!
robot.mouseClick();

Then for listening I use nw.js:

https://github.com/nwjs/nw.js/wiki/Shortcut

You can wrap the Robot Class provided by Java for a cross platform solution using the node-java module.

Working example:

var java = require('java');

var Robot = java.import('java.awt.Robot');
var robot = new Robot();

robot.mouseMoveSync(0, 0);

Take a look at https://github.com/Loknar/node-macmouse

$ npm install macmouse

example.js

var mouse = require('macmouse');

mouse.init();

var ptX = 800;
var ptY = 600;

var doThings = function() {
    mouse.Place(ptX, ptY);
    setTimeout(pressAndHold, 250);
}

var pressAndHold = function() {
    mouse.LeftButtonPress();
    setTimeout(doDragStuff, 250);
}

var doDragStuff = function() {
    ptX += 2;
    ptY += 2;
    mouse.DragPlace(ptX, ptY);
    setTimeout(doDragStuff, 250);
}

doThings();

mouse.quit();